Take the NYS Thruway to exit 28, Fonda/Fultonville. Turn left after exiting, then right over the bridge. Turn left on Route 5. Proceed approximately 1½ miles (through Fonda, staying on Route 5) to the National Kateri Tekakwitha Shrine. The Shrine is on the right with good parking.
Click this link for a map: Map to Kateri Shrine